Fear erasure in mice requires synergy between antidepressant drugs and extinction training
Research in Hermo Pharma founder's laboratory shows that a combination of an antidepressant drug and fear extinction training can lead to erasure of conditioned fear responses in mice. The current study provides neurobiological evidence that may explain clinical observations that a combination of antidepressant medication and psychological treatment works more effectively for mood disorders than either therapy on their own.
Professor Eero Castrén's research continues on the same line that led to the discovery of Hermo Pharma's HER-801 therapeutic concept for treatment of adult amblyopia, which is also based on pharmacological modulation of neuronal plasticity in adult brain.
Karpova NN, Pickenhagen A, Lindholm J, Tiraboschi E, Kulesskaya N, Agústsdóttir A, Antila H, Popova D, Akamine Y, Sullivan R, Hen R, Drew LJ, Castrén E (2011). Fear erasure in mice requires synergy between antidepressant drugs and extinction training. Science 334: 1731-1734. PMID: 22194582